CARDIOMETABOLIC HEALTH

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Heart disease is the
leading cause of death
in both the acute and
chronic stages after
spinal cord injury.

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The Efficacy and Safety of Rosuvastatin for Modifying Bone Mass and Cardiometabolic Disease Outcomes - RoBaCO is a collaborative, multi-center clinical trial conducted at Lyndhurst Centre in Toronto and at the University of Miami Miller School of Medicine. This study aims to determine the efficacy and safety of rosuvastatin (a cholesterol medication) for augmenting bone density and cardiometabolic disease risk among adults with chronic motor-complete spinal cord injury (SCI). The study seeks to determine whether rosuvastatin;

  • Improves bone mineral density (BMD) and decreases fracture risk

  • Has an effect on biomarkers, specifically markers of bone metabolism and inflammatory stress

  • Improve bone quality and structure using peripheral quantitative computed tomography

  • Improves arterial stiffness, measured using pulse wave velocity (PWV)

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The Rehabilitation Interventions For Individuals With a SCI in the Community (RIISC).

The RIISC team aims to develop and implement innovative, multimodal, and inter-professional community-based rehabilitation solutions aiming to optimize bone health (e.g., osteoporosis, fracture risk), and minimize the negative effects associated with sarcopenic obesity (e.g., risk of diabetes and heart disease) in Ontario and Quebec.

We aim to:

  • Work with community partners to deliver physical exercise programs for people living with SCI

  • Implement cardiometabolic indicators linked to newly published guidelines

  • Development an early version of SCI-FX, an app to estimate fracture risk

  • Share expertise between scientist and clinicians in Ontario and Quebec

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THE CHOICES PROJECT

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The CHOICES project was a multi-centre project that examined the benefits of optimized exercise and targeted education to clinicians on cardiovascular health with the aim of reducing chronic disease for Canadians living with SCI.

 

  • The study aimed to determine whether body weight-supported treadmill training (BWSTT) had beneficial effects, over and above arm-cycle ergometry training (ACET) on indicators of cardiovascular disease (CVD) risk in individuals with spinal cord injury (SCI).

  • Arterial stiffness. measured using pulse wave velocity (PWV), was used a prognostic indicator of CVD.

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